Animal Cell Culture Bioreactors

It addresses engineering aspects such as mass transfer instrumentation and control ensuring successful design and operation of animal cell bioreactors.

Animal cell culture bioreactors.

The new bioreactor called the see saw bioreactor is ideal for the growth of cells with a sensitive membrane. Critical contamination points for a bioreactor are the transitions between sterile spaces such as the stirrer ports and gas lines. In one case a bioreactor is a vessel in which a chemical process is carried out which involves organisms or biochemically active substances derived from such organisms. Animal cell culture control for bioprocess engineering presents the design fabrication and control of a new type of bioreactor meant especially for animal cell line culture.

This process can either be aerobic or anaerobic these bioreactors are commonly cylindrical ranging in size from litres. There are several types of bioreactors including stirred tank airlift hollow fiber and rotary cell culture system rccs d. The gas sparging of culture broth causes damage to suspended animal cells. The new bioreactor called the see saw bioreactor is ideal for the growth of cells with a sensitive membrane.

This article examines the underlying mechanisms involved in bubble associated cell damage and the methods available for controlling such damage. One bacterial spore or vegetative bacterial cell is all it takes to overgrow an animal cell culture. Microcarriers with adherent cells which were in principle an adaptation of homogeneous culture systems used for. Morphological and biochemical features of two major mammalian cell groups.

Animal cell culture bioreactors initially employed stirred tanks containing. However despite this sparged bioreactors remain the preferred means of cell culture because sparging is a robust method of supplying oxygen especially on a large scale. Purpose of this article is to review the current status of bioreactor design for mammalian cell culture. Bioreactors play a key role in the field of biologics where they are used for the production of recombinant therapeutic proteins by large scale cultivation of animal cells.

Cell cultures are particularly susceptible to biological contamination. Animal cell culture control for bioprocess engineering presents the design fabrication and control of a new type of bioreactor meant especially for animal cell line culture.